Blog By – Vaishali Khanna– BFY Faculty
PCOS is a common endocrine disorder.The primary lesion is unknown.Patients have a steady state of relatively high estrogen,androgen and Leutinizing Hormone(LH) rather than fluctuating condition seen in ovulating women.Increased levels of estrone come fro conversion of ovarian and adrenal androgens to estrone in body fat(in obesity cases).The high estrone levels are believed to cause suppression of pituitary Follicle Stimulating Hormone(FSH) and a relative increase in LH.Constant LH stimulation of the ovary results in anovulation,multiple cysts and theca cell hyperplasia with excess androgen output.
In addition,there is insulin resistance leading to high levels of insulin in the blood which further leads to weight gain and obesity.
It is very important to distinguish between PCO (Polycystic ovaries) and PCOS (Polycystic ovary syndrome).Having PCO does not necessarily mean you have PCOS. A syndrome is usually defined as a pattern of symptoms belonging to particular disease.Medical studies using ultrasound have found that around one in four women has polycystic ovaries(PCO),but most of them have none or few of the other symptoms associated with PCOS.
- Excess hair on the body(Hirsutism)
- Acne and other Skin problems
- Scalp hair loss
- Irregular or missed periods
- Heavy periods
- Fertility problem
- Insulin Resistance
- Weight issues
Even if specific symptoms are not causing an immediate problem, PCOS can have significant long term effects,including diabetes,heart disease and endometrial or breast cancer.This happens because of unopposed estrogen secretion.
In addition they show hyperinsulinemia and insulin resistance which leads to early onset diabetes type II and therefore hyperlipidemia and its complications.